The Columbus Crew gave up a late goal Wednesday night and fell to Orlando City SC 2-1.
The Crew fell behind early when Orlando's Chris Mueller found the back of the net in the 27th minute.
In the 52nd minute, Orlando went a man down when Nani received a red card.
Just four minutes later, Harrison Afful scored on a left-footed strike from just inside the 18-yard box to tie the game.
Despite being a man down, Orlando took a 2-1 lead when Benji Michel scored in the 84th minute.
The Crew will be back in action Sunday when it takes on Atlanta United at 3:30 p.m.